Science of Sustainability is a focused effort to further address the academic needs of students in high needs Indiana schools by enhancing their teachers’ abilities to use technological tools to foster students’ scientific investigations, explanations and argumentation in regards to sustainability issues in their local community. This project is grounded in the research literature that emphasizes technology enhanced data collection and analysis to foster students’ reasoning abilities. The project extends the development and mobilization of a comprehensive STEM support network for teachers that will provide the wrap-around support necessary to make the innovative curricular changes necessary to address the new Indiana State Academic Standards for science. The support comes from a regional community of practice among teachers, science and science education experts, STEM professionals, and the resources, facilities, and materials of environmental and community-based non-profits. The Center for P-16 Research and Collaboration at Indiana University’s School of Education facilitates the project among high school teachers and faculty from the Indiana University-Bloomington’s School of Education and the Gary Community School Corporation.